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X-linked hyper IgM syndrome, resulting in high levels of serum IgM and low levels of serum IgG, is caused by a defect in CD40L expression. The specific immune event that would be prevented by a defective CD40L would be | |
A. | activation of B cells by T-independent antigens [Wrong Answer] |
B. | failure of B cells to provide co-stimulation for Th2 activation [Wrong Answer] |
C. | failure of Th2 cells to provide co-stimulation for B cell isotype switching [Correct Answer] |
D. | failure of Th2 cells to provide co-stimulation for B cell proliferation [Wrong Answer] |