Question is ⇒ Which of the following abnormality, resulted from the inheritance of an unbalanced complement of chromosomes can be diagnosed through karotyping?, Options are ⇒ (A) Down's syndrome, (B) Turner's syndrome, (C) Klinefelter's syndrome, (D) all of these, (E) , Leave your comments or Download question paper.

Question is ⇒ Which of the following abnormality, resulted from the inheritance of an unbalanced complement of chromosomes can be diagnosed through karotyping?, Options are ⇒ (A) Down's syndrome, (B) Turner's syndrome, (C) Klinefelter's syndrome, (D) all of these, (E) , Leave your comments or Download question paper. Previous question Next question


Q1.	Which of the following abnormality, resulted from the inheritance of an unbalanced complement of chromosomes can be diagnosed through karotyping?
A.	Down's syndrome [Wrong Answer]
B.	Turner's syndrome [Wrong Answer]
C.	Klinefelter's syndrome [Wrong Answer]
D.	all of these [Correct Answer]
View Answer 1 -1 Explanation:- Answer : D Discuss it below : !! OOPS Login [Click here] is required to post your answer/result Help other students, write article, leave your comments

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⇒ According to Eagle, the growth of L-strain and Hela-strain cultures require to have mandatory presence of
6 amino acids
8 amino acids
10 amino acids
12 amino acids

⇒ Which of the followings are the metabolic products of glucose and glutamine?
CO₂ and NH₃
CO₂ and lactate
Lactate and ammonium
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⇒ During the growth of animal cells in culture, it is noticed that the cells do not look very healthy. After an investigation, this is found that there is a lot of lactic acid in the culture fluid. What is probably wrong with this culture?
Ethyl alcohol is being produced in excess
The cells have too much oxygen
Glycolysis is being inhibited
The cells do not have enough oxygen

⇒ For culturing, plasma from the adult chicken is preferred to mammalian plasma because
it forms a clear and solid coagulum even after dilution
it is too opaque
it doesn't produce solid clots
it forms a semi solid coagulum

⇒ Specific oxygen consumption rates for mammalian cells are in the range of (where n and p represents to nano and pico respectively)
0.05-5 nmol of O₂/cell/h
5 - 10 nmol of O₂ /cell/h
0.05-5 pmol of O₂/cell/h
5 - 10 pmol of O₂/cell/h

⇒ The major problem associated with the isolation of free cells and cell aggregates from organs is that of
releasing the cells from their supporting matrix
inhibiting the cells from their supporting matrix
disintegrating the cells from their supporting matrix
none of the above

⇒ Which of the following is correct?
ECL can be established in suspension cultures whereas it is exceptional for primary cell lines (PCL)
ECL and PCL can be established in suspension cultures
PCL can be established in suspension cultures
none of the above

⇒ The human fibroplast is a classical example of
stable primary cell lines
established cell lines
cell transformations
none of these

⇒ Range of osmolarity tolerated/accepted in mOsm/Kg of H₂O by mammalian cells is
150-300
280-360
300-325
360-400

⇒ Toxicity due to accumulation of ammonia can be overcome
by substituting glutamine by glutamate
by controlled addition of glutamine at low level
by removal of ammonia or ammonium from culture medium
all of the above

⇒ How does CO₂ help in the cell metabolism during cell culture?
It participates in the de novo synthesis of purines and pyrimidines
Helps in the cells respiration
For monitoring pH of the culture
All of the above

⇒ Which of the following is incorrect?
Established cell lines (ECL) have short doubling time
ECL are invariably aneuploid
ECL grow in higher density
ECL do not show much evidence of spatial orientation

⇒ PH of culture medium is initially controlled by
presence of CO₂
presence of bicarbonate buffer
addition of bases
none of these

⇒ Which of the following is not the explantation technique?
Slide culture
Carrel flask culture
Roller test tube culture
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⇒ Which of the following abnormality, resulted from the inheritance of an unbalanced complement of chromosomes can be diagnosed through karotyping?
Down's syndrome
Turner's syndrome
Klinefelter's syndrome
all of these

⇒ At low glucose concentration, below 0.25 mmol/litre, large portions of glucose and glutamine is shunted via
oxidative pathway
anaerobic pathway
both (a) and (b)
none of these

⇒ In animal cell culture, particularly mammalian cell culture, transformation means
uptake of new genetic material
phenotypic modifications of cells in culture
both (a) and (b)
release of genetic information

⇒ Higher dissolved oxygen concentration in the culture media are toxic and lead to
DNA degradation
lipid peroxidation
metabolism of nutrients in culture media at a rate greater than that required for consumption
all of the above

⇒ Cells which have undergone transformation frequently become
anchorage independent
anchorage dependent
stable
unstable

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physical disruption
enzymatic digestion
treating with chelating agents
all of the above

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7-15 mmol/litre
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1-10%
10-15%
15-20%

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high glutamine concentration is required
low glucose concentration is required
high glucose concentration is required

⇒ What are the main constituents of culture for animal cell growth?
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no change in pH
reduction in the pH of culture hence loss of cell viability
no loss of cell viability

⇒ What is the effect of excess accumulation of metabolite products (lactate and ammonium) on cells?
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They act as growth inhibitors
Have no effect on cells
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5.5 - 55 mmol/litre
55 - 75 mmol/litre
75-105 mmol/litre
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inhibiting respiration
altering intracellular pH by diffusing across cell membrane
both (a) and (b)
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