Question is ⇒ Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the, Options are ⇒ (A) absence of human immune response against murine proteins (HAMA) response, (B) presence of HAMA response, (C) poor recognition of immunoglobulin, Ig constant regions, (D) all of the above, (E) , Leave your comments or Download question paper.

Question is ⇒ Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the, Options are ⇒ (A) absence of human immune response against murine proteins (HAMA) response, (B) presence of HAMA response, (C) poor recognition of immunoglobulin, Ig constant regions, (D) all of the above, (E) , Leave your comments or Download question paper. Previous question Next question


Q1.	Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the
A.	absence of human immune response against murine proteins (HAMA) response [Correct Answer]
B.	presence of HAMA response [Wrong Answer]
C.	poor recognition of immunoglobulin, Ig constant regions [Wrong Answer]
D.	all of the above [Wrong Answer]
View Answer 1 -1 Explanation:- Answer : A Discuss it below : !! OOPS Login [Click here] is required to post your answer/result Help other students, write article, leave your comments

Previous question Next question

Also Read Similar Questions Below :

⇒ In monoclonal antibody technology, tumor cells that can replicate endlessly are fused with mammalian cells that produce an antibody. The result of this cell fusion is a
hybridoma
myeloma
natural killer cell
lymphoblast

⇒ Which of the following is incorrect?
MAbs can be used to diagnose or treat diseases
MAbs can be used in tumor scanning
MAbs canbe used in cancer diagnosis
MAbs can not be used in such non-infectious diseases as those of endocrine system

⇒ A cytokine that stimulates the activity of B and T cells is
lymphotoxin
interlukin-2
interlukin-1
all of these

⇒ The EBV-hybridoma technique
immortalizes the donor Bcells
facilitates the proliferation of antigen specific B cells
gives much higher hybridization frequencies
all of the above

⇒ Helper T cells assist in the functions of
certain B cells
certain T cells
certain B cells and other T cells
none of the above

⇒ The cross linkage of antigens by antibodies is known as
agglutination
complement fixation
a cross reaction
all of these

⇒ In immuno-inflammatory diseases such as hemolytic anaemia, eczema etc.,
T8 cells are greatly reduced
T8 cells are greatly increased
T4 cells are greatly reduced
T4 cells are greatly increased

⇒ Which of the following is correct?
rabbits do not make myelomas whereas mice are unable to synthesize antibodies
rabbits do not make myelomas whereas mice are able to synthesize antibodies
rabbits make myelomas whereas mice are unable to synthesize antibodies
rabbits make myelomas whereas mice are able to synthesize antibodies

⇒ T_C cells are important in controlling
virus infections
allergy
autoimmunity
all of these

⇒ An example of mosaic antigen is
virus
bacteria
a hapten
protein

⇒ Preliminary clinical results with a humanized antibody against the interleukin-2 receptor have suggested the
absence of human immune response against murine proteins (HAMA) response
presence of HAMA response
poor recognition of immunoglobulin, Ig constant regions
all of the above

⇒ The Ig locus is about
2/3^rd of all hybridomas
l/3^rd of all hybridomas
l/2^nd of all hybridomas
1/4^th of all hybridomas

⇒ The primary B cell receptor is
IgD
IgG
IgA
IgE

⇒ T cells are the source of
interleukin
interferon
lymphotoxin
all of these

⇒ The approach (s), which is/are currently followed to produce human monoclonal antibodies, is/are known as
transformation of antigen specific B lymphocytes (EBV)
hybridization of 6-thioguanine-resistant human plasmacytoma with immune human lymphocytes
combination of EB Vand hybridoma techniques
all of these

⇒ The antigen-specific lymphocytes can be immortalized by which of the following method?
Transfection with tumor derived DNA
Hybridization with a suitable lymphoid tumor cell
Transformation following infection by Epstein-Barr virus (EB V)
All of the above

⇒ Small simple molecules are
poor antigens
rich antigens
moderate antigens
heterophilic antigens

⇒ It is highly valued if the lymphocytes derived from the lymph node or tonsil tend to undergo fusion at
high frequencies
moderate frequencies
low frequencies
at no frequency

⇒ In human B cells and T cells are matured in the
bone marrow and thymus respectively
lymph nodes and spleen respectively
bursa and thymus respectively
none of these

⇒ Some cross reactions with monoclonal antibodies (MAbs) can occur. Unexpected cross reactions occur more frequently with
Ig MAbs
IgG
IgA
IgE

⇒ The hybrid cells can be propagated
in tissue culture
as ascites in peritoneal cavity of mice
both (a) and (b)
none of these

⇒ Which type of cell actually secrets antibodies?
plasma cells
T cells
macrophages
dendritic cells